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- This may be of clinical importance because the plasma concentrations of the metabolites are as high as or higher than those of bupropion.
- In addition, there have been rare, spontaneous postmarketing reports of erythema multiforme, Stevens-Johnson syndrome, and anaphylactic shock associated with bupropion.
- Data from the United Healthcare database and a case-control study 6,853 infants with cardiovascular malformations and 5,763 with non-cardiovascular malformations from the National Birth Defects Prevention Study NBDPS did not show an increased risk for cardiovascular malformations overall after bupropion exposure during the first trimester.
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Ensure an adequate airway, oxygenation, clinical situations?
Monitoring of blood pressure is recommended in patients who receive the combination of bupropion and nicotine replacement? The times to peak concentrations for the erythrohydrobupropion and threohydrobupropion metabolites are similar to that of the hydroxybupropion metabolite.
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